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Purpose: The purpose of the CFG Wiki Paradigm Pages is to involve Participating Investigators (PIs) in demonstrating how the CFG has made progress against its overall goal to 'define paradigms by which protein-carbohydrate interactions mediate cell communication.' To lay the foundation for this vision, the CFG Steering Committee assembled a team of PIs to identify “Paradigms” that represented exemplary glycan binding proteins (GBPs) for each major family. Ultimately, 30 Paradigms were selected to cover 9 families of GBPs. The Paradigms share two key characteristics: they are representative of many other GBPs in their family, and they have clear biological functions that have become better understood through the use of CFG resources. Combined, the Paradigms cover the majority of the mammalian and microbial GBPs that are within the scope of the CFG, and show how the CFG has driven progress in the field as a whole.
Process: The CFG's Paradigm Pages are open to contributions from all CFG Participating Investigators. To obtain editing privileges, you must first request an user account. If you already have one, simply log in.
Focus: For consistency between Paradigm Pages, please maintain the 30 selected paradigm glycan-binding proteins that are listed on the paradigm pages and the standard outline and formatting of each individual Paradigm Page. The CFG would be particularly grateful to PIs for filling in the gaps regarding:
Progress toward understanding this GBP paradigm. This section includes five subheadings that together address the 7 specific aims of the CFG.

  • Carbohydrate ligands: Describe progress that has been made towards defining the specificity and affinity of this GBP for carbohydrate ligands and identifying the glycan ligand(s) that mediate GBP binding.
  • Cellular expression of GBP and ligands: Describe progress that has been made towards establishing the cell types involved in cell communication.
  • Biosynthesis of ligands: Describe progress that has been made towards identifying the glycosyltransferases that synthesize carbohydrate ligands for the GBP and determining whether regulation of glycosylation modulates GBP function.
  • Structure: Describe progress that has been made towards determining the structure of the GBP.
  • Biological roles of GBP-ligand interaction: Describe progress that has been made towards determining how GBP-ligand interactions mediate cell communication.
    CFG resources used in investigations. This section documents how investigators have used CFG resources to assess the function of the GBP paradigm.
  • Describe use (or non-use) of CFG resources including glycan profiling, glycogene microarray screening, knockout mouse analysis, and glycan array screening.
  • Include hyperlinks to relevant datasets in the CFG databases.
    Other related GBPs. List related GBPs believed to have similar functions.
    References. Citations will appear here once references are added to the above sections.

    How to edit the CFG Paradigm Pages:
    • Click the 'Log in' link in the top right-hand corner.
    • Login or request a new account (enter any text in the 'biography' box) and wait for administrative approval. If you forgot your password, click 'E-mail new password'.
    • From the Paradigm Pages, find the paradigm GBP you are interested in. Follow the link to that page.
    • Click the 'edit' tab at the top of the page.
    • You will see a text box containing all of the text and html tags that make up that Paradigm Page.
    • Contribute 2-3 sentences for each of the blank fields (e.g. 'Progress toward understanding this GBP paradigm').
    • If you can, contribute to the 'CFG resources used in investigations' section, including links to specific datasets in the CFG database.
    • For formatting and addition of hyperlinks and references, use common html tags (see table).
      Tip: Copy and paste text from the edit box of another Wiki page that contains the formatting style you would like to emulate.
    • Click 'Show preview' below the editing box.
    • When finished, click 'Save page'.
    • For more help editing Wiki pages, visit the Wikipedia markup help page.
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